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A brief calibration reads where you are today, setting the starting difficulty for the session ahead.
Meet Meliora
A precision digital therapeutic for major depressive disorder — adaptive cognitive training, wrapped in an immersive narrative people actually want to return to.
What it is
Treatment, disguised as a game
Meliora pairs adaptive cognitive training with an immersive narrative to deliver an evidence-led intervention for depression — not gamified wellness.
It targets the cognitive deficits and fronto-parietal hypoactivity that medication and talk therapy don't directly address. Each session trains attention, working memory and cognitive control through play, while the story keeps people engaged long enough for treatment to take hold.
- Adaptive difficulty driven by in-session performance
- Narrative built to sustain engagement and adherence
- Designed as a clinical treatment, not a wellness app
Investigational — not yet cleared by regulators.
Inside Meliora
Three views of the same system
An engine that meets each patient where they are
Meliora continuously reads in-session performance — accuracy, reaction time, error patterns — and recalibrates difficulty to keep training in the optimal challenge zone: hard enough to drive change, never so hard that people disengage.
The training tasks are designed to exercise attention, working memory and cognitive control: the executive functions most disrupted in depression. Because the adaptation is personalized, two patients can play the same chapter and follow entirely different difficulty curves.
A story worth coming back to
Adherence is where most digital interventions fail. Meliora wraps its clinical mechanics inside an immersive narrative with characters, world and progression — so returning each day feels like continuing a game, not completing a chore.
Pacing, rewards and story beats are tuned to reinforce the treatment schedule rather than compete with it. The result is a therapeutic dose delivered through something people genuinely want to play.
Built to fit clinical workflows
Meliora is being developed as a prescribable, evidence-based treatment that can complement — not replace — existing care. Baseline profiling and ongoing in-game measures are designed to give clinicians a structured view of cognitive and symptom change over time.
Soihtu DTx is pursuing the clinical evidence and regulatory pathway required for use in care settings.
Investigational — not yet cleared by regulators. Not a substitute for professional medical advice.
A typical session
How a session works
Play & train
You progress through the story while the engine adapts each task in real time to keep you in the optimal zone.
Consolidate
Sessions end on a high point and feed the next, building a consistent, adherent treatment rhythm over weeks.
By the numbers
Designed around a real routine
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Typical session length
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Sessions per week (program)
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Core treatment arc
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Target adherence (program)
Figures are illustrative of the program design and not clinical outcomes. Investigational — not yet cleared by regulators.
Common questions
About Meliora
No. Meliora is being developed as a treatment that can complement existing care by targeting cognitive symptoms that medication and talk therapy don't directly address. Care decisions should always be made with a qualified clinician.
Meliora is designed as a clinical intervention with a defined mechanism, a structured treatment arc, and a clinical evidence and regulatory pathway — not a general wellness or commercial brain-training product.
An adaptive engine reads in-session performance and recalibrates task difficulty in real time, so the level of challenge is continuously tuned to each individual rather than fixed in advance.
It is being developed for adults with major depressive disorder. Eligibility, indications and access will be defined as the clinical and regulatory program progresses.
Meliora is investigational and not yet cleared by regulators. To follow progress or discuss clinical and research partnerships, please get in touch.
Want to go deeper?
Read the science behind Meliora, or talk to us about clinical and research collaboration.