Research & insights

Notes from the lab and the studio — clinical trial updates, the neuroscience behind Meliora, cognitive-training science, product design and company news.

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Latest writing

Meliora trial readout: sustained symptom reduction at 12 weeks

Our latest cohort showed clinically meaningful reductions in depressive symptoms, with effect sizes comparable to psychotherapy but reached faster. Investigational — not yet cleared by regulators.

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Re-engaging fronto-parietal circuits in major depression

Why hypoactivity in the fronto-parietal control network is a tractable target — and how adaptive gameplay is designed to recruit it session after session.

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Designing Meliora: narrative that earns the next session

A look at how our game designers balance therapeutic load with story, so adherence comes from immersion rather than streaks and badges.

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Cognitive training, properly dosed: the case against gamified wellness

Difficulty that adapts to in-session performance keeps training in the optimal zone — the difference between a treatment and a distraction.

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What our outcome measures actually track

From PHQ-9 to objective cognitive endpoints — how we measure whether Meliora is working, and why we report the limits as plainly as the wins.

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€3M+ raised to bring precision DTx to depression care

Funding from Techstars, Innovestor, Newfund and the Aalto Start-Up Center extends our clinical roadmap and grows the team in Espoo.

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Personalization, end to end: how Meliora tunes to each patient

Baseline profiling, real-time difficulty and pacing — the adaptive loop that makes the same product fit very different people.

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Designing a large-scale trial for a digital therapeutic

Recruitment, controls and engagement tracking when your intervention is software — lessons from standing up our pivotal study.

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Soihtu DTx joins the Techstars 2023 cohort

Selected into the 2023 Techstars Accelerator, joining a global program supporting promising early-stage health and technology companies.

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A decade of research, distilled into a video game

How ten years of Aalto University neuroscience on cognition and depression became the foundation for a precision digital therapeutic.

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